Chemical Structure : P053
CAS No.:
2748196-63-4
P053
(P-053;CerS1 inhibitor P053)
Catalog No.: PC-35607Not For Human Use, Lab Use Only.
P053 (P-053, CerS1 inhibitor P053) is a potent, selective, orally active inhibitor of ceramide synthase 1 (CerS1) with IC50 of 0.5 uM, displays >10-fold selectivity for inhibition of CerS2, CerS4, CerS5, and CerS6.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
P053 (P-053, CerS1 inhibitor P053) is a potent, selective, orally active inhibitor of ceramide synthase 1 (CerS1) with IC50 of 0.5 uM, displays >10-fold selectivity for inhibition of CerS2, CerS4, CerS5, and CerS6.
P053 (P-053, CerS1 inhibitor P053) selectively reduces C18 sphingolipids in cultured cells, with no effect on HEK293 cell viability at or below 1 uM.
P053 (P-053, CerS1 inhibitor P053) increases fatty acid oxidation in skeletal muscle and impedes increases in muscle triglycerides and adiposity in mice fed a HFD, but does not protect against HFD-induced insulin resistance.
P053 (P-053, CerS1 inhibitor P053) increases palmitate oxidation and mitochondrial respiratory capacity in SkM.
Physicochemical Properties
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M.Wt
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354.271
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Formula
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C18H21Cl2NO2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20 °C 12 Months; 4°C 6 Months
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- In Solvent
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-80 °C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(S)-2-amino-4-(4-(3,4-dichlorobenzyloxy)phenyl)-2-methylbutan-1-ol
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References
1. Turner N, et al. Nat Commun. 2018 Aug 21;9(1):3165.
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