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P053

Chemical Structure : P053

CAS No.: 2748196-63-4

P053 (P-053;CerS1 inhibitor P053)

Catalog No.: PC-35607Not For Human Use, Lab Use Only.

P053 (P-053, CerS1 inhibitor P053) is a potent, selective, orally active inhibitor of ceramide synthase 1 (CerS1) with IC50 of 0.5 uM, displays >10-fold selectivity for inhibition of CerS2, CerS4, CerS5, and CerS6.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

P053 (P-053, CerS1 inhibitor P053) is a potent, selective, orally active inhibitor of ceramide synthase 1 (CerS1) with IC50 of 0.5 uM, displays >10-fold selectivity for inhibition of CerS2, CerS4, CerS5, and CerS6.
P053 (P-053, CerS1 inhibitor P053) selectively reduces C18 sphingolipids in cultured cells, with no effect on HEK293 cell viability at or below 1 uM.
P053 (P-053, CerS1 inhibitor P053) increases fatty acid oxidation in skeletal muscle and impedes increases in muscle triglycerides and adiposity in mice fed a HFD, but does not protect against HFD-induced insulin resistance.
P053 (P-053, CerS1 inhibitor P053) increases palmitate oxidation and mitochondrial respiratory capacity in SkM.

Physicochemical Properties

M.Wt 354.271
Formula C18H21Cl2NO2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(S)-2-amino-4-(4-(3,4-dichlorobenzyloxy)phenyl)-2-methylbutan-1-ol

References

1. Turner N, et al. Nat Commun. 2018 Aug 21;9(1):3165.

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