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P11

Chemical Structure : P11

CAS No.: 942285-55-4

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P11 (PAFAH inhibitor P11)

Catalog No.: PC-62386Not For Human Use, Lab Use Only.

PAFAH inhibitor P11 (P11) is a potent, selective platelet-activating factor acetylhydrolases PAFAH1b2 and PAFAH1b3 inhibitor with IC50 of 40 nM and 900 nM respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    PAFAH inhibitor P11 (P11) is a potent, selective platelet-activating factor acetylhydrolases PAFAH1b2 and PAFAH1b3 inhibitor with IC50 of 40 nM and 900 nM respectively.
    P11 blocks PAFAH1b2- and PAFAH1b3-mediated hydrolysis of the substrate PAF to lyso-PAF with IC50 values of 36 nM and 880 nM.
    P11 impairs tumor cell survival; in situ-active and can be used to investigate the cellular functions of PAFAH1b2/3.

    Physicochemical Properties

    M.Wt 503.7
    Formula C30H33NO4S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (2R,6R)-rel-2-[4-(1,1-dimethylethyl)phenyl]-1,2,5,6-tetrahydro-6-(4-methylphenyl)-1-[(4-methylphenyl)sulfonyl]-3-pyridinecarboxylic acid

    References

    1. Chang JW, et al. ACS Chem Biol. 2015 Apr 17;10(4):925-32.

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