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P2119

Chemical Structure : P2119

CAS No.: 1978372-41-6

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P2119 (P-2119)

Catalog No.: PC-38281Not For Human Use, Lab Use Only.

P2119 (P-2119) is an anticoronaviruse chemical probe that inhibit SARS-CoV-2 Spike binding to human ACE2 receptor.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    P2119 (P-2119) is an anticoronaviruse chemical probe that inhibit SARS-CoV-2 Spike binding to human ACE2 receptor.
    P2119 inhibits infection by human coronaviruses, including SARS-CoV-2, and decreases the binding of spike glycoprotein to its receptor ACE2.
    P2119 targets a conserved hydrophobic binding pocket in the RBD with the benzyl thiol-reducing moiety pointed directly toward Cys432.
    P2119 inhibits the SARS-CoV-2 infection by shifting the spike glycoprotein redox scaffold.

    Physicochemical Properties

    M.Wt 511.583
    Formula C21H37NO11S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (2R,2'R,3R,3'R,4R,4'R,5S,5'S)-6,6'-((2-(4-(mercaptomethyl)phenoxy)ethyl)azanediyl)bis(hexane-1,2,3,4,5-pentaol)

    References

    1. Yunlong Shi, et al. Proc Natl Acad Sci U S A. 2022 Feb 8;119(6):e2120419119.

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