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P2165

Chemical Structure : P2165

CAS No.: 2035055-88-8

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P2165 (P-2165)

Catalog No.: PC-38282Not For Human Use, Lab Use Only.

P2165 (P-2165) is a anticoronaviruse chemical probe that inhibit SARS-CoV-2 Spike binding to human ACE2 receptor.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    P2165 (P-2165) is a anticoronaviruse chemical probe that inhibit SARS-CoV-2 Spike binding to human ACE2 receptor.
    P2165 inhibits infection by human coronaviruses, including SARS-CoV-2, and decreases the binding of spike glycoprotein to its receptor ACE2.
    P2165 targets a conserved hydrophobic binding pocket in the RBD with the benzyl thiol-reducing moiety pointed directly toward Cys432.
    P2165 inhibits the SARS-CoV-2 infection by shifting the spike glycoprotein redox scaffold.

    Physicochemical Properties

    M.Wt 557.67
    Formula C22H39NO11S2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1,1′-[[2-[3,4-Bis(mercaptomethyl)phenoxy]ethyl]imino]bis[1-deoxy-D-mannitol]

    References

    1. Yunlong Shi, et al. Proc Natl Acad Sci U S A. 2022 Feb 8;119(6):e2120419119.

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