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P218 hydrochloride

Chemical Structure : P218 hydrochloride

CAS No.: 1142407-60-0

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P218 hydrochloride

Catalog No.: PC-26680Not For Human Use, Lab Use Only.

P218 hydrochloride is a highly potent inhibitor of Plasmodium falciparum dihydrofolate reductase (PfDHFR) with Ki of 0.54 nM for quadruple mutant P. falciparum DHFR, inhibits wild-type P. falciparum (TM4) and quadruple mutant P. falciparum (V1/S) with IC50 of 4.6 nM and 56 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

P218 hydrochloride is a highly potent inhibitor of Plasmodium falciparum dihydrofolate reductase (PfDHFR) with Ki of 0.54 nM for quadruple mutant P. falciparum DHFR, inhibits wild-type P. falciparum (TM4) and quadruple mutant P. falciparum (V1/S) with IC50 of 4.6 nM and 56 nM.

Physicochemical Properties

M.Wt 396.87
Formula C18H25ClN4O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-(2-(3-((2,4-diamino-6-ethylpyrimidin-5-yl)oxy)propoxy)phenyl)propanoic acid hydrochloride

References

1. Decharuangsilp S, et al. Eur J Med Chem. 2026 Apr 19;313:118863.

2. Yuthavong Y, et al. Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):16823-8.

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