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P2X7R antagonist A20

Chemical Structure : P2X7R antagonist A20

CAS No.: 3033478-33-7

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P2X7R antagonist A20 (Compound 9q)

Catalog No.: PC-27099Not For Human Use, Lab Use Only.

P2X7R antagonist A20 (Compound 9q) is a potent, selective antagonist of ATP-gated channel P2X7 receptor (P2X7R) with IC50 of 18 nM (hP2X7), exhibits non-competitive negative allosteric mode of antagonism.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

P2X7R antagonist A20 (Compound 9q) is a potent, selective antagonist of ATP-gated channel P2X7 receptor (P2X7R) with IC50 of 18 nM (hP2X7), exhibits non-competitive negative allosteric mode of antagonism.

Physicochemical Properties

M.Wt 351.38
Formula C18H13N3O3S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(quinolin-8-ylcarbamothioyl)benzo[d][1,3]dioxole-5-carboxamide

References

1. Abid Mahmood, et al. Eur J Med Chem. 2022 Aug 5:238:114491.

2. Malik I, et al. Inflammopharmacology. 2026 Jun 17. doi: 10.1007/s10787-026-02297-0.

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