You are here:Home-Chemical Inhibitors & Agonists-Proteasome/Ubiquitin-Deubiquitinase (DUB)-P5091
P5091

Chemical Structure : P5091

CAS No.: 882257-11-6

P5091 (P005091)

Catalog No.: PC-21561Not For Human Use, Lab Use Only.

P5091 is a potent, specific inhibitor of ubiquitin-specific protease 7 (USP7) with IC50 of 4.2 uM, does not inhibit other DUBs or other families of cysteine proteases (EC50> 100 uM).

Packing Price Stock Quantity
10 mg $128 In stock
25 mg $198 In stock
50 mg $288 In stock
100 mg Get quote
200 mg Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

P5091 is a potent, specific inhibitor of ubiquitin-specific protease 7 (USP7) with IC50 of 4.2 uM, does not inhibit other DUBs or other families of cysteine proteases (EC50> 100 uM).
P5091 does not inhibit other DUBs such as USP5, UCHL1, or UCHL3.
P5091 inhibits USP7-, but not USP2- or USP8-mediated cleavage of poly K48 linked ubiquitin chains.
P5091 induces HDM2 polyubiquitylation, and accelerate degradation of HDM2.
P5091 inhibits USP7 activity, induces MM cell death, and overcomes bortezomib-resistance.

Physicochemical Properties

M.Wt 348.21
Formula C12H7Cl2NO3S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1-(5-((2,3-Dichlorophenyl)thio)-4-nitrothiophen-2-yl)ethan-1-one

References

1. Chauhan D, et al. Cancer Cell. 2012 Sep 11;22(3):345-58.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: