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PAANIB-1

Chemical Structure : PAANIB-1

CAS No.: 2634726-71-7

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PAANIB-1

Catalog No.: PC-38697Not For Human Use, Lab Use Only.

PAANIB-1 is a brain-penetrant PAAN/MIF nuclease inhibitor that prevents neurodegeneration that prevents neurodegeneration induced by α-syn PFF, AAV-α-syn overexpression, or MPTP intoxication in vivo.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    PAANIB-1 is a brain-penetrant PAAN/MIF nuclease inhibitor that prevents neurodegeneration that prevents neurodegeneration induced by α-syn PFF, AAV-α-syn overexpression, or MPTP intoxication in vivo.

    Physicochemical Properties

    M.Wt 1169.34
    Formula C62H81FN6O15
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (12S,182S,4R,10S,13S,16S,E)-16-(tert-butoxymethyl)-4-(3,4-dimethoxyphenethyl)-55-fluoro-9,10,15,20,28,28-hexamethyl-13-phenyl-3,6,26-trioxa-9,12,15,20-tetraaza-1(2,1)-piperidina-18(1,2)-pyrrolidina-5(1,3)-benzenacyclotriacontaphan-23-ene-2,8,11,14,17,19,25,29,30-nonaone

    References

    1. Hyejin Park, et al. Cell. 2022 May 5;S0092-8674(22)00467-6. doi: 10.1016/j.cell.2022.04.020.

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