Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : PACMA31
Catalog No.: PC-70360Not For Human Use, Lab Use Only.
An orally active, irreversible inhibitor of protein disulfide isomerase (PDI), forming a covalent bond with the active site cysteines of PDI.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
An orally active, irreversible inhibitor of protein disulfide isomerase (PDI), forming a covalent bond with the active site cysteines of PDI; significantly inhibits human ovarian cancer cells OVCAR-8, HEY, and OVCAR-8 growth with IC50 of 0.9, 1.4, and 0.32 uM; significantly suppresses ovarian tumor growth without causing toxicity to normal tissues in mouse xenograft model of human OVCAR-8 ovarian cancer.
| M.Wt | 430.47 | |
| Formula | C21H22N2O6S | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Xu S, et al. Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16348-53.
2. Vatolin S, et al. Cancer Res. 2016 Jun 1;76(11):3340-50.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
