PAR-2 inhibitor I-117

Chemical Structure : PAR-2 inhibitor I-117

Catalog No.: PC-26473Not For Human Use, Lab Use Only.

PAR-2 inhibitor I-117 is a potent, selective Protease-Activated Receptor-2 (PAR-2) negative allosteric modulator / antagonist with IC50 of 0.09 nM.

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Biological Activity

PAR-2 inhibitor I-117 is a potent, selective Protease-Activated Receptor-2 (PAR-2) negative allosteric modulator / antagonist with IC50 of 0.09 nM.

M.Wt	593.10
Formula	C32H34ClFN4O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-(4-(7-(tert-butyl)-5-(4-chloro-3-fluorophenyl)furo[3,2-b]pyridine-2-carbonyl)-3,3-dimethylpiperazin-1-yl)-2,4-dimethylnicotinic acid

1. Samya Aouad, et al. J Immunother Cancer. 2026 Apr 3;14(4):e013507.

2. Patent WO2018057588.