Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : PAT-048
Catalog No.: PC-60639Not For Human Use, Lab Use Only.
PAT-048 (PAT048) is a potent, selective, noncompetitive autotaxin inhibitor with IC50 of 1.1 nM against the lysoPLD activity of human ATX.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
PAT-048 (PAT048) is a potent, selective, noncompetitive autotaxin inhibitor with IC50 of 1.1 nM against the lysoPLD activity of human ATX.
PAT-048 exhibits good potency for inhibition of lysoPLD activity with IC50 of 8.9 nM and 22 nM in human blood and mouse plasma, respectively.
PAT-048 decreases ATX activity systemically and in the lung, without effect on pulmonary LPA or fibrosis in bleomycin-challenged mice.
| M.Wt | 461.912 | |
| Formula | C22H18ClF2N3O2S | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Black KE, et al. FASEB J. 2016 Jun;30(6):2435-50.
2. Castelino FV, et al. Arthritis Rheumatol. 2016 Dec;68(12):2964-2974.
3. Bain G, et al. J Pharmacol Exp Ther. 2017 Jan;360(1):1-13.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
