PAT-048 (PAT048) is a potent, selective, noncompetitive autotaxin inhibitor with IC50 of 1.1 nM against the lysoPLD activity of human ATX.
PAT-048 exhibits good potency for inhibition of lysoPLD activity with IC50 of 8.9 nM and 22 nM in human blood and mouse plasma, respectively.
PAT-048 decreases ATX activity systemically and in the lung, without effect on pulmonary LPA or fibrosis in bleomycin-challenged mice.
