PAT-1251 | LOXL2 inhibitor | Probechem Biochemicals

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Chemical Structure : PAT-1251

CAS No.: 2007885-39-2

PAT-1251 (Lenumlostat; GB2064; PAT1251)

Catalog No.: PC-61128Not For Human Use, Lab Use Only.

Lenumlostat (GB2064, PAT1251) is a potent, selective and orally bioavailable lysyl oxidase-like 2 (LOXL2) inhibitor with IC50 of 0.71 uM in human whole blood assays, with high selectivity over LOX (400-fold) and other amine oxidases.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Lenumlostat (GB2064, PAT1251) is a potent, selective and orally bioavailable lysyl oxidase-like 2 (LOXL2) inhibitor with IC50 of 0.71 uM in human whole blood assays, with high selectivity over LOX (400-fold) and other amine oxidases.
PAT1251 exhibits efficacy in mouse bleomycin lung fibrosis model.

Physicochemical Properties

M.Wt	399.346
Formula	C18H17F4N3O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(3-((4-(aminomethyl)-6-(trifluoromethyl)pyridin-2-yl)oxy)phenyl)((3R,4R)-3-fluoro-4-hydroxypyrrolidin-1-yl)methanone

References

1. Rowbottom MW, et al. J Med Chem. 2017 May 25;60(10):4403-4423.

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PAT-1251 (Lenumlostat; GB2064; PAT1251)

Biological Activity

Physicochemical Properties

References

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