Chemical Structure : PAT-505 sodium
CAS No.:
1782070-85-2
PAT-505 sodium
Catalog No.: PC-23710Not For Human Use, Lab Use Only.
PAT-505 sodium (PAT 505, PAT505) is a potent, selective, noncompetitive, and orally active autotaxin inhibitor with IC50 of 2.0 nM against the lysoPLD activity of human ATX.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
PAT-505 sodium (PAT 505, PAT505) is a potent, selective, noncompetitive, and orally active autotaxin inhibitor with IC50 of 2.0 nM against the lysoPLD activity of human ATX.
PAT-505 displays high selectivity over other ENPP proteins and no significant agonist or antagonist activity at PPARα and PPARγ.
PAT-505 maintains good potency for inhibition of lysoPLD activity with IC50 of 9.7 nM and 62 nM in human blood and mouse plasma, respectively.
PAT-505 robustly reduces liver fibrosis with no significant effect on steatosis, hepatocellular ballooning, or inflammation in high-fat diet model of NASH.
Physicochemical Properties
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M.Wt
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495.90
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Formula
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C23H17ClF2N3NaO2S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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3-((6-chloro-2-cyclopropyl-1-(1-ethyl-1H-pyrazol-4-yl)-7-fluoro-1H-indol-3-yl) thio)-2-fluorobenzoic acid sodium salt
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References
1. Bain G, et al. J Pharmacol Exp Ther. 2017 Jan;360(1):1-13.
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