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PAT1inh-A0030

Chemical Structure : PAT1inh-A0030

CAS No.: 1030097-65-4

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PAT1inh-A0030

Catalog No.: PC-21358Not For Human Use, Lab Use Only.

PAT1inh-A0030 is a potent and selective SLC26A6 (putative anion transporter 1, PAT1) inhibitor with IC50 of 1.0 uM, shows no activity on relevant ion transporters/channels (SLC26A3, SLC26A4, SLC26A9, CFTR, TMEM16A).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    PAT1inh-A0030 is a potent and selective SLC26A6 (putative anion transporter 1, PAT1) inhibitor with IC50 of 1.0 uM, shows no activity on relevant ion transporters/channels (SLC26A3, SLC26A4, SLC26A9, CFTR, TMEM16A).
    PAT1inh-A0030 inhibited fluid absorption in the ileum of wild-type and CF mice (CftrdelF508/delF508) with >90% prevention of a decrease in loop fluid volume and loop weight/length ratio in a closed-loop model of intestinal fluid absorption.

    Physicochemical Properties

    M.Wt 326.36
    Formula C17H18N4O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    ethyl 4-(benzyl(methyl)amino)-3-methylisoxazolo[5,4-d]pyrimidine-6-carboxylate

    References

    1. Tifany Chu, et al. RSC Med Chem. 2023 Sep 14;14(11):2342-2347.

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