Chemical Structure : PAV-104
CAS No.:
2923674-83-1
PAV-104
(PAV104)
Catalog No.: PC-20900Not For Human Use, Lab Use Only.
PAV-104 (PAV104) is a novel viral assembly inhibitor, shows potent anti-SARS-CoV-2 activity in Calu-3 cells with EC50 of 1.7 nM and EC90 of 23.5 nM, inhibits the oligomerization of the SARS-CoV-2 nucleocapsid.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
PAV-104 (PAV104) is a novel viral assembly inhibitor, shows potent anti-SARS-CoV-2 activity in Calu-3 cells with EC50 of 1.7 nM and EC90 of 23.5 nM, inhibits the oligomerization of the SARS-CoV-2 nucleocapsid.
PAV-104 is more potent than remdesivir (EC50 =7.9 nM and EC90 =218.1 nM).
PAV-104 exerts potent antiviral activity against a broad range of circulating SARS-CoV-2 variants in human primary airway epithelial cells (AECs).
PAV-104 specifically inhibits virus-like particle production, and blocks SARS-CoV-2 replication through targeting the viral assembly/budding process.
PAV-104 interacts with N and interferes with nucleocapsid oligomerization.
PAV-104 suppresses the 'maturation of nucleoprotein' signaling pathway reinforces inhibition of viral assembly/budding.
Physicochemical Properties
|
M.Wt
|
581.69
|
|
Formula
|
C29H35N5O6S
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
O=C(C1=CC(C2CC2)=NN1C)NCC3=CC=CC(OCC4=CC=C(C(N5CCN(S(=O)(C)=O)CC5)=O)C=C4)=C3OC
|
References
1. Satish Pillai, et al. Res Sq. 2023 May 17;rs.3.rs-2887435.
Contact Us
sales@probechem.com
