PAX inhibitor BG1 (PAX-IN-BG1) is a small molecule inhibitor that attenuate Pax-2 transactivation ability with IC50 of 1.5 uM.
BG1 also shows ability to inhibit Pax5 and Pax8 activation of the PRS4-Luc reporter assays.
BG1 inhibits Pax2-positive cancer cell growth and target gene expression but has little effect on Pax2-negative cells.
BG1 prevent Pax protein interactions with the histone H3K4 methylation complex at Pax target genes (Cdh6) in renal cells.
