PBD-150 | Glutaminyl cyclase inhibitor

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Chemical Structure : PBD-150

CAS No.: 790663-33-1

PBD-150 (PBD 150, PBD150)

Catalog No.: PC-60393Not For Human Use, Lab Use Only.

PBD150 is a potent glutaminyl cyclase (QC) inhibitor with Ki of 60 nM.

Packing	Price	Stock
5 mg	$118	In stock
10 mg	$178	In stock
25 mg	$298	In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

PBD150 is a potent glutaminyl cyclase (QC) inhibitor with Ki of 60 nM.
PBD150 significantly reduces depositions of Aβ3(pGlu)-40/42 in brain in transgenic mouse models and Drosophila model of Alzheimer diseas.

Physicochemical Properties

M.Wt	320.411
Formula	C15H20N4O2S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(3,4-dimethoxyphenyl)-3-(3-imidazol-1-ylpropyl)thiourea

References

1. Cynis H, et al. Biochemistry. 2008 Jul 15;47(28):7405-13.

2. Huang KF, et al. J Biol Chem. 2011 Apr 8;286(14):12439-49.

3. Buchholz M, et al. J Med Chem. 2006 Jan 26;49(2):664-77.

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PBD-150 (PBD 150, PBD150)

Biological Activity

Physicochemical Properties

References

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