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Chemical Structure : PBD-150
CAS No.: 790663-33-1
Catalog No.: PC-60393Not For Human Use, Lab Use Only.
PBD150 is a potent glutaminyl cyclase (QC) inhibitor with Ki of 60 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $118 | In stock | |
| 10 mg | $178 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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PBD150 is a potent glutaminyl cyclase (QC) inhibitor with Ki of 60 nM.
PBD150 significantly reduces depositions of Aβ3(pGlu)-40/42 in brain in transgenic mouse models and Drosophila model of Alzheimer diseas.
| M.Wt | 320.411 | |
| Formula | C15H20N4O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
1-(3,4-dimethoxyphenyl)-3-(3-imidazol-1-ylpropyl)thiourea |
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1. Cynis H, et al. Biochemistry. 2008 Jul 15;47(28):7405-13.
2. Huang KF, et al. J Biol Chem. 2011 Apr 8;286(14):12439-49.
3. Buchholz M, et al. J Med Chem. 2006 Jan 26;49(2):664-77.
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