PBENZ-DBRMD

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Chemical Structure : PBENZ-DBRMD

Catalog No.: PC-38162Not For Human Use, Lab Use Only.

PBENZ-DBRMD is a first-in-class inhibitor of enzyme iodothyronine deiodinase type 3 (DIO3) with antitumor effects both in vitro and in vivo.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

PBENZ-DBRMD is a first-in-class inhibitor of enzyme iodothyronine deiodinase type 3 (DIO3) with antitumor effects both in vitro and in vivo.
PBENZ-DBRMD demonstrated attenuated cell counts, induction in apoptosis, and a reduction in cell proliferation in DIO3-positive HGSOC cells (OVCAR3 and KURAMOCHI), but not in DIO3-negative normal ovary cells (CHOK1) and OVCAR3 depleted for DIO3 or its substrate, T3.

Physicochemical Properties

M.Wt	374.972
Formula	C11H5Br2NO4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(3,4-dibromo-2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)benzoic acid

References

1. Dotan Moskovich, et al. Oncogene. 2021 Nov;40(44):6248-6257.

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PBENZ-DBRMD

Biological Activity

Physicochemical Properties

References

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