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PCC0208057

Chemical Structure : PCC0208057

CAS No.:

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PCC0208057 (PCC-0208057)

Catalog No.: PC-22083Not For Human Use, Lab Use Only.

PCC0208057 is a potent, selective TRPC6 channel inhibitor, inhibits TRPC6-mediated Ca2+ concentration increase with IC50 of 2.44 uM, binds directly to TRPC6.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

PCC0208057 is a potent, selective TRPC6 channel inhibitor, inhibits TRPC6-mediated Ca2+ concentration increase with IC50 of 2.44 uM, binds directly to TRPC6.
PCC0208057 inhibits the proliferation of prostate cancer cells, induces cell cycle arrest at G2/M phase.
PCC0208057 increases the phosphorylation of NFAT and Cdc2, inhibits the migration of prostate cancer cells.
PCC0208057 inhibits the invasion and metastasis of prostate cancer cells.
PCC0208057 (50 mg/kg and 100 mg/kg) has good antitumor efficacy in nude mice.

Physicochemical Properties

M.Wt 425.50
Formula C22H23N3O4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(4-methoxybenzo[d]thiazol-2-yl)-N-(2-(pyrrolidin-1-yl)ethyl)benzo[d][1,3]dioxole-5-carboxamide

References

1. Yingjie Wei, et al. Front Pharmacol. 2024 Mar 18:15:1352373.

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