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PD128907 hydrochloride

Chemical Structure : PD128907 hydrochloride

CAS No.: 300576-59-4

PD128907 hydrochloride (PD 128907 hydrochloride)

Catalog No.: PC-70058Not For Human Use, Lab Use Only.

PD128907 hydrochloride is a potent, selective and orally active agonist of dopamine D3 receptor (D3R) with Ki of 20 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

PD128907 hydrochloride is a potent, selective and orally active agonist of dopamine D3 receptor (D3R) with Ki of 20 nM.
PD128907 hydrochloride displays 18-200-fold selectivity over other dopamine receptor subtypes.
PD128907 hydrochloride decreases dopamine release both in rat striatum, nucleus accumbens and medial frontal cortex, decreases spontaneous locomotor activity (LMA) in rats; orally active.

Physicochemical Properties

M.Wt 285.77
Formula C14H19NO3.HCl
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(4aR,10bR)-4-propyl-3,4,4a,10b-tetrahydro-2H,5H-chromeno[4,3-b][1,4]oxazin-9-ol hydrochloride

References

1. DeWald HA, et al. J Med Chem. 1990 Jan;33(1):445-50.

2. Pugsley TA, et al. J Pharmacol Exp Ther. 1995 Dec;275(3):1355-66.

3. Bristow LJ, et al. Neuropharmacology. 1996 Mar;35(3):285-94.

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