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Chemical Structure : PD168368
Catalog No.: PC-21220Not For Human Use, Lab Use Only.
PD168368 is a potent, competitive, and selective neuromedin B receptor (NMB-R) antagonist with Ki of 15 nM, IC50 of 96 nM.
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PD168368 is a potent, competitive, and selective neuromedin B receptor (NMB-R) antagonist with Ki of 15 nM, IC50 of 96 nM.
PD 168368 also is a mixed FPR1/FPR2/FPR3 agonist with EC50 of 0.57, 0.24, and 2.7 nM, respectively.
PD168368 is highly active and stimulated [Ca2+]I release in human neutrophils with EC50 values in the nanomolar range.
PD168368 suppresses migration and invasion of the human breast cancer cell line MDA-MB-231.
PD168368 reduces epithelial-mesenchymal transition (EMT) of breast cancer cells by E-cadherin upregulation and vimentin downregulation.
PD168368 suppresses the activation of mTOR/p70S6K/4EBP1 and AKT/GSK-3β pathways in breast cancer cells.
PD168368 potently inhibits in vivo metastasis of breast cancer.
| M.Wt | 554.65 | |
| Formula | C31H34N6O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. R R Ryan, et al. J Pharmacol Exp Ther. 1999 Sep;290(3):1202-11.
2. K Tokita, et al. J Biol Chem. 2001 Jan 5;276(1):495-504.
3. Igor A Schepetkin, et al. Mol Pharmacol. 2011 Jan;79(1):77-90.
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