Chemical Structure : PD168368
CAS No.:
204066-82-0
PD168368
(PD 168368)
Catalog No.: PC-21220Not For Human Use, Lab Use Only.
PD168368 is a potent, competitive, and selective neuromedin B receptor (NMB-R) antagonist with Ki of 15 nM, IC50 of 96 nM.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
PD168368 is a potent, competitive, and selective neuromedin B receptor (NMB-R) antagonist with Ki of 15 nM, IC50 of 96 nM.
PD 168368 also is a mixed FPR1/FPR2/FPR3 agonist with EC50 of 0.57, 0.24, and 2.7 nM, respectively.
PD168368 is highly active and stimulated [Ca2+]I release in human neutrophils with EC50 values in the nanomolar range.
PD168368 suppresses migration and invasion of the human breast cancer cell line MDA-MB-231.
PD168368 reduces epithelial-mesenchymal transition (EMT) of breast cancer cells by E-cadherin upregulation and vimentin downregulation.
PD168368 suppresses the activation of mTOR/p70S6K/4EBP1 and AKT/GSK-3β pathways in breast cancer cells.
PD168368 potently inhibits in vivo metastasis of breast cancer.
Physicochemical Properties
|
M.Wt
|
554.65
|
|
Formula
|
C31H34N6O4
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
(S)-3-(1H-indol-3-yl)-2-methyl-2-(3-(4-nitrophenyl)ureido)-N-((1-(pyridin-2-yl)cyclohexyl)methyl)propanamide
|
References
1. R R Ryan, et al. J Pharmacol Exp Ther. 1999 Sep;290(3):1202-11.
2. K Tokita, et al. J Biol Chem. 2001 Jan 5;276(1):495-504.
3. Igor A Schepetkin, et al. Mol Pharmacol. 2011 Jan;79(1):77-90.
Contact Us
sales@probechem.com
