Chemical Structure : PD173074
CAS No.: 219580-11-7
Catalog No.: PC-42521Not For Human Use, Lab Use Only.
PD173074 is a potent, selective, ATP-competitive FGFR1 inhibitor with IC50 of ~25 nM.
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	PD173074 is a potent, selective, ATP-competitive FGFR1 inhibitor with IC50 of ~25 nM.
	PD173074 also inhibits autophosphorylation of VEGFR2 with IC50 of 100–200 nM.
	PD173074 displays >1000-fold selectivity over Src, InsR, EGFR, PDGFR, etc.
| M.Wt | 523.6702 | |
| Formula | C28H41N7O3 | |
| Appearance | Solid | |
| Storage | 
                            
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| Solubility | 
                             DMSO: ≥ 52 mg/mL  | 
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| Chemical Name/SMILES | 
                             Urea, N-[2-[[4-(diethylamino)butyl]amino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)-  | 
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1. Mohammadi M, et al. EMBO J. 1998 Oct 15;17(20):5896-904.
2. Skaper SD, et al. J Neurochem. 2000 Oct;75(4):1520-7.
3. Nguyen PT, et al. Br J Cancer. 2013 Oct 15;109(8):2248-58.

                
                
                
                
                
                
                
                
            
            
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