Catalog No.: PC-27296Not For Human Use, Lab Use Only.
PD176252 is a potent antagonist of neuromedin-B preferring (BB1, NMBR) and gastrin-releasing peptide-preferring (BB2) receptor (GRPR) with Kis of 0.17 nM and 1 nM for human BB1 and BB2 receptors, and 0.66 nM, 16 nM for Rat BB1 and BB2 receptors, respectively.
PD176252 is a potent antagonist of neuromedin-B preferring (BB1, NMBR) and gastrin-releasing peptide-preferring (BB2) receptor (GRPR) with Kis of 0.17 nM and 1 nM for human BB1 and BB2 receptors, and 0.66 nM, 16 nM for Rat BB1 and BB2 receptors, respectively. PD176252 inhibits (125I-Tyr0) neuromedin B binding with IC50 of 50 nM. PD176252 (1 uM) significantly inhibited colony number using a proliferation assay in vitro.
