Chemical Structure : PDSinh-C01
CAS No.:
2128304-65-2
PDSinh-C01
Catalog No.: PC-27732Not For Human Use, Lab Use Only.
PDSinh-C01 is a specific small molecule inhibitor of Cl-/HCO3- exchanger Pendrin (SLC26A4), inhibits Cl−/anion exchange mediated by mouse pendrin with IC50 of 1-3 uM, without affecting other major kidney tubule transporters.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
PDSinh-C01 is a specific small molecule inhibitor of Cl-/HCO3- exchanger Pendrin (SLC26A4), inhibits Cl−/anion exchange mediated by mouse pendrin with IC50 of 1-3 uM, without affecting other major kidney tubule transporters.
PDSinh-C01 (25 uM) does not significantly inhibit the transport activities of Slc4a1 (anion exchanger 1 [AE1]), Slc26a3 (chloride anion exchanger [CLD]/downregulated-in-adenoma [DRA]), Na-K-Cl cotransporter (NKCC1;Slc12a2), or ENaC.
PDSinh-C01 potentiates the acute diuretic efficacy of furosemide.
PDSinh-C01 reduces the diuretic efficacy of hydrochlorothiazide.
Physicochemical Properties
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M.Wt
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401.54
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Formula
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C20H23N3O2S2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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5-(3,4-dimethyl-1H-pyrazol-5-yl)-2-methyl-N-(1,2,3,4-tetrahydronaphthalen-1-yl)thiophene-3-sulfonamide
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References
1. Lipani A, et al. Eur J Med Chem. 2026 Jan 15;302(Pt 2):118325.
2. Onur Cil, et al. J Am Soc Nephrol. 2016 Dec;27(12):3706-3714.
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