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Chemical Structure : PEAQX
CAS No.: 459836-30-7
Catalog No.: PC-42957Not For Human Use, Lab Use Only.
PEAQX (NVP-AAM077) is a potent, selective, NR2A-preferring NMDA receptor antagonist with IC50 of 270 nM (NR1A/2A), >100-fold selectivity over NR1A/2B receptor (IC50=29,600 nM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $168 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | $528 | In stock | |
| 100 mg | $898 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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PEAQX (NVP-AAM077) is a potent, selective, NR2A-preferring NMDA receptor antagonist with IC50 of 270 nM (NR1A/2A), >100-fold selectivity over NR1A/2B receptor (IC50=29,600 nM).
PEAQX (NVP-AAM077) shows high binding affinity for NMDA receptors (IC50=8 nM), induces social facilitation in adolescent male rats (1.25, 3.75mg/kg).
PEAQX (NVP-AAM077) enhances locomotor activity in response to PCP challenge in vivo.
| M.Wt | 454.2117 | |
| Formula | C17H17BrN3O5P | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Phosphonic acid, P-[[[(1S)-1-(4-bromophenyl)ethyl]amino](1,2,3,4-tetrahydro-2,3-dioxo-5-quinoxalinyl)methyl]- |
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1. Auberson YP, et al. Bioorg Med Chem Lett. 2002 Apr 8;12(7):1099-102.
2. Anastasio NC, et al. Neuroscience. 2009 Nov 10;163(4):1181-91.
3. Bortolato M, et al. J Neurosci. 2012 Jun 20;32(25):8574-82.
4. Morales M, et al. Psychopharmacology (Berl). 2014 Apr;231(8):1797-807.
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