PEPCKi | PEPCK inhibitor | Probechem Biochemicals

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Chemical Structure : PEPCKi

PEPCKi (PEPCK inhibitor)

Catalog No.: PC-38630Not For Human Use, Lab Use Only.

PEPCKi is a small molecule inhibitor of hosphoenolpyruvate carboxykinase (PEPCK), blocks lactate utilization and impairs tumor growth in colorectal cancer.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

PEPCKi is a small molecule inhibitor of hosphoenolpyruvate carboxykinase (PEPCK), blocks lactate utilization and impairs tumor growth in colorectal cancer.
The metabolic enzyme phosphoenolpyruvate carboxykinase (PEPCK; HUGO: PCK1) increases colon cancer cell growth in part by promoting the use of both glucose and glutamine by the TCA cycle.

Physicochemical Properties

M.Wt	463.513
Formula	C25H26FN5O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[4-[[3-Butyl-1-[(2-fluorophenyl)methyl]-2,3,6,9-tetrahydro-2,6-dioxo-1H-purin-8-yl]methyl]phenyl]acetamide

References

1. Emily D Montal, et al. Cancer Metab. 2019 Aug 1;7:8.

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