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PF-00446687

Chemical Structure : PF-00446687

CAS No.: 862281-92-3

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PF-00446687 (PF-446687, PF00446687)

Catalog No.: PC-60214Not For Human Use, Lab Use Only.

PF-00446687 (PF-446687) is a potent, selective melanocortin-4 receptor (MC4R) agonist with EC50 of 12 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    PF-00446687 (PF-446687) is a potent, selective melanocortin-4 receptor (MC4R) agonist with EC50 of 12 nM.
    PF-00446687 displays >100-fold selectivity over MC1R/1 uM).
    PF-00446687 is find to be active in preliminary human trials, with the 200mg dose being of similar effectiveness to 100mg sildenafil, though lower doses were ineffective.

    Physicochemical Properties

    M.Wt 470.593
    Formula C28H36F2N2O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    [(3S,4R)-1-tert-butyl-4-(2,4-difluorophenyl)pyrrolidin-3-yl]-[(3S,5R)-4-hydroxy-3,5-dimethyl-4-phenylpiperidin-1-yl]methanone

    References

    1. Lansdell MI, et al. J Med Chem. 2010 Apr 22;53(8):3183-97.

    2. Modi ME, et al. Neuropsychopharmacology. 2015 Jul;40(8):1856-65.

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