SNX-5422 (PF-04929113) mesylate | HSP90 inhibitor

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Chemical Structure : PF-04929113 Mesylate

CAS No.: 1173111-67-5

PF-04929113 Mesylate (SNX-5422 Mesylate, PF04929113 Mesylate)

Catalog No.: PC-42460Not For Human Use, Lab Use Only.

SNX-5422 (PF-04929113) mesylate is the prodrug of PF-04928473 (SNX-2112), a potent, orally bioavailable HSP90 inhibitor, inhibits several signaling pathways and induces apoptosis in CRPC LNCaP tumors in vivo.

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5 mg	$78	In stock
10 mg	$118	In stock
25 mg	$198	In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

SNX-5422 (PF-04929113) mesylate is the prodrug of PF-04928473 (SNX-2112), a potent, orally bioavailable HSP90 inhibitor, inhibits several signaling pathways and induces apoptosis in CRPC LNCaP tumors in vivo.

Physicochemical Properties

M.Wt	617.6377
Formula	C26H34F3N5O7S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	Glycine, trans-4-[[2-(aminocarbonyl)-5-[4,5,6,7-tetrahydro-6,6-dimethyl-4-oxo-3-(trifluoromethyl)-1H-indazol-1-yl]phenyl]amino]cyclohexyl ester, methanesulfonate (1:1)

References

1. Lamoureux F, et al. Clin Cancer Res. 2011 Jul 15;17(14):4916.

2. Rajan A, et al. Clin Cancer Res. 2011 Nov 1;17(21):6831-9.

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PF-04929113 Mesylate (SNX-5422 Mesylate, PF04929113 Mesylate)

Biological Activity

Physicochemical Properties

References

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