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Chemical Structure : PF-06282999
CAS No.: 1435467-37-0
Catalog No.: PC-45604Not For Human Use, Lab Use Only.
PF-06282999 is a potent, highly selective and irreversible inhibitor of myeloperoxidase (MPO) with Kinact/KI of 116000 M-1s-1.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $198 | In stock | |
| 50 mg | $288 | In stock | |
| 100 mg | $458 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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PF-06282999 is a potent, highly selective and irreversible inhibitor of myeloperoxidase (MPO) with Kinact/KI of 116000 M-1s-1.
PF-06282999 displays high selectivity for MPO over TPO and cytochrome P450 isoforms.
PF-06282999 shows excellent pharmacological and pharmacokinetic profile.
PF-06282999 is orally active.
| M.Wt | 325.7707 | |
| Formula | C13H12ClN3O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 32 mg/mL |
|
| Chemical Name/SMILES |
1(2H)-Pyrimidineacetamide, 6-(5-chloro-2-methoxyphenyl)-3,4-dihydro-4-oxo-2-thioxo- |
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1. Ruggeri RB, et al. J Med Chem. 2015 Nov 12;58(21):8513-28.
2. Dong JQ, et al. Drug Metab Dispos. 2016 Feb;44(2):209-19.
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