Catalog No.: PC-60632Not For Human Use, Lab Use Only.
PF-06409577(PF06409577, PF 6409577) is a potent, selective AMPK β1-containing isoforms activator with TR-FRET EC50 of 7.0 and 6.8 nM for α1β1γ1 and α2β1γ1, respectively.
PF-06409577 (PF06409577, PF 6409577) is a potent, selective AMPK β1-containing isoforms activator with TR-FRET EC50 of 7.0 and 6.8 nM for α1β1γ1 and α2β1γ1, respectively.
PF-06409577 displays no activity for α1β2γ1/α2β2γ1/α2β2γ3 with EC50 >40 uM.
PF-06409577 elevates the phosphorylation of AMPK in the kidney, without impacting blood glucose levels.
PF-06409577 and reduces the progression of proteinuria in rat model of diabetic nephropathy.
