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Chemical Structure : PF-06409577
CAS No.: 1467057-23-3
Catalog No.: PC-60632Not For Human Use, Lab Use Only.
PF-06409577(PF06409577, PF 6409577) is a potent, selective AMPK β1-containing isoforms activator with TR-FRET EC50 of 7.0 and 6.8 nM for α1β1γ1 and α2β1γ1, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $368 | In stock | |
| 100 mg | $568 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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PF-06409577 (PF06409577, PF 6409577) is a potent, selective AMPK β1-containing isoforms activator with TR-FRET EC50 of 7.0 and 6.8 nM for α1β1γ1 and α2β1γ1, respectively.
PF-06409577 displays no activity for α1β2γ1/α2β2γ1/α2β2γ3 with EC50 >40 uM.
PF-06409577 elevates the phosphorylation of AMPK in the kidney, without impacting blood glucose levels.
PF-06409577 and reduces the progression of proteinuria in rat model of diabetic nephropathy.
| M.Wt | 341.79 | |
| Formula | C19H16ClNO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
6-Chloro-5-[4-(1- hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic acid |
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1. Cameron KO, et al. J Med Chem. 2016 Sep 8;59(17):8068-81.
2. Salatto CT, et al. J Pharmacol Exp Ther. 2017 May;361(2):303-311.
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