PF-06462894 | mGluR5 NAM | Probechem Biochemicals

Chemical Structure : PF-06462894

PF-06462894 (PF 06462894, PF06462894)

Catalog No.: PC-61058Not For Human Use, Lab Use Only.

PF-06462894 is a potent, subtype-selective mGluR5 negative allosteric modulator with Ki of 6.1 nM.

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Biological Activity

PF-06462894 is a potent, subtype-selective mGluR5 negative allosteric modulator with Ki of 6.1 nM.
PF-06462894 possesses favorable properties and a predicted low clinical dose (2 mg twice daily).
PF-06462894 does not show any evidence of immune activation in a mouse drug allergy model.

Physicochemical Properties

M.Wt	329.4
Formula	C18H23N3O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-6-Neopentyl-2-(pyridin-2-ylmethoxy)-6,7-dihydropyrimido[2,1-c][1,4]oxazin-4(9H)-one

References

1. Stepan AF, et al. J Med Chem. 2017 Sep 28;60(18):7764-7780.

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PF-06462894 (PF 06462894, PF06462894)

Biological Activity

Physicochemical Properties

References

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