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Chemical Structure : PF-07054894
Catalog No.: PC-20761Not For Human Use, Lab Use Only.
PF-07054894 is a potent, functionally selective CCR6 antagonist, blocks in vitro CCL20- dependent human T cell chemotaxis with IC50 of 5.7 nM.
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PF-07054894 is a potent, functionally selective CCR6 antagonist, blocks in vitro CCL20- dependent human T cell chemotaxis with IC50 of 5.7 nM.
PF-07054894 dispays negligible activity (<12% over basal activity) in an assay panel of 168 G protein-coupled receptors, with more than 30% inhibition of agonist-dependent activity on only 3 receptors: CCR6, CCR7, and CXCR2.
PF-07054894 displays >50- and 150-fold functional selectivity relative to CCR7 and CXCR2.
PF-07054894 increased the frequency of CCR6+ peripheral blood T cells suggesting that blockade of CCR6 inhibited homeostatic migration of T cells from blood to tissues of naïve cynomolgus monkeys.
PF-07054894 caused an increase in cell surface CCR6 in mouse and monkey B cells which was recapitulated in mouse splenocytes in vitro.
| M.Wt | 466.54 | |
| Formula | C24H30N6O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Wei Li, et al. J Pharmacol Exp Ther. 2023 May 4;JPET-AR-2022-001452.
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