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Chemical Structure : PF-07059013
Catalog No.: PC-72609Not For Human Use, Lab Use Only.
PF-07059013 (PF 07059013) is a potent, noncovalent modulator of sickled hemoglobin (HbS), specifically binds to Hb with nanomolar affinity (Ki=0.6 nM) and displays strong partitioning into RBCs.
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PF-07059013 (PF 07059013) is a potent, noncovalent modulator of sickled hemoglobin (HbS), specifically binds to Hb with nanomolar affinity (Ki=0.6 nM) and displays strong partitioning into RBCs.
PF-07059013 showed concentration dependent blood binding in human blood, substantially decrease RBC sickling in vivo.
PF-07059013 has advanced to phase 1 clinical trials for treatment of sickle cell disease (SCD).
| M.Wt | 365.368 | |
| Formula | C19H16FN5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Gopalsamy A, et al. J Med Chem. 2021 Jan 14;64(1):326-342.
2. Knee KM, et al. Am J Hematol. 2021 Aug 1;96(8):E272-E275.
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