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PF-07059013

Chemical Structure : PF-07059013

CAS No.: 2435610-93-6

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PF-07059013 (PF 07059013)

Catalog No.: PC-72609Not For Human Use, Lab Use Only.

PF-07059013 (PF 07059013) is a potent, noncovalent modulator of sickled hemoglobin (HbS), specifically binds to Hb with nanomolar affinity (Ki=0.6 nM) and displays strong partitioning into RBCs.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    PF-07059013 (PF 07059013) is a potent, noncovalent modulator of sickled hemoglobin (HbS), specifically binds to Hb with nanomolar affinity (Ki=0.6 nM) and displays strong partitioning into RBCs.
    PF-07059013 showed concentration dependent blood binding in human blood, substantially decrease RBC sickling in vivo.
    PF-07059013 has advanced to phase 1 clinical trials for treatment of sickle cell disease (SCD).

    Physicochemical Properties

    M.Wt 365.368
    Formula C19H16FN5O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-6-(1-((2-Amino-6-fluoroquinolin-3-yl)oxy)ethyl)-5-(1H-pyrazol-1-yl)pyridin-2(1H)-one

    References

    1. Gopalsamy A, et al. J Med Chem. 2021 Jan 14;64(1):326-342.

    2. Knee KM, et al. Am J Hematol. 2021 Aug 1;96(8):E272-E275.

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