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PF-07202954

Chemical Structure : PF-07202954

CAS No.: 2639372-47-5

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PF-07202954 (PF 07202954)

Catalog No.: PC-21285Not For Human Use, Lab Use Only.

PF-07202954 is a potent, selective next-generation DGAT2 inhibitor with IC50 of 10 nM (hDGAT2).

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

PF-07202954 is a potent, selective next-generation DGAT2 inhibitor with IC50 of 10 nM (hDGAT2).
PF-07202954 exhibits rat DGAT2 in vitro potency similar to that of human (IC50=17 nM).
PF-07202954 display high selectivity against related acyltransferases (DGAT1, MGAT1, MGAT2, and MGAT3: all IC50 > 50,000 nM) and a broad off-target panel.
PF-07202954 (3-100 mg/ kg) dose dependenlyly reduces hepatic and circulating triglycerides, along with SREBP target gene expression reduction, in Western-diet-fed rats.

Physicochemical Properties

M.Wt 438.46
Formula C22H23FN6O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(5-((3-ethoxypyridin-2-yl)oxy)pyridin-3-yl)-N-((3S,5S)-5-fluoropiperidin-3-yl)pyrimidine-5-carboxamide

References

1. Kevin J Filipski, et al. ACS Med Chem Lett. 2023 Oct 2;14(10):1427-1433.

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