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Chemical Structure : PF-07258669
Catalog No.: PC-49760Not For Human Use, Lab Use Only.
PF-07258669 (PF 07258669) is a potent, selective, and orally bioavailable melanocortin-4 receptor (MC4R) antagonist with Ki of 0.46 nM and human MC4R inverse agonist potency (IC50=13 nM).
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PF-07258669 (PF 07258669) is a potent, selective, and orally bioavailable melanocortin-4 receptor (MC4R) antagonist with Ki of 0.46 nM and human MC4R inverse agonist potency (IC50=13 nM).
PF-07258669 weakly binds hMC3R, hMC5R and hMC1R with Ki values of 340 nM, 840 nM, and >1600 nM, respectively.
PF-07258669 showed robust in vivo efficacy in an aged rat in vivo model of geriatric anorexia.
| M.Wt | 462.53 | |
| Formula | C25H27FN6O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Michelle R Garnsey, et al. J Med Chem. 2023 Feb 19. doi: 10.1021/acs.jmedchem.2c02012.
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