Chemical Structure : PF-07304814
CAS No.:
2468015-78-1
PF-07304814
(PF 07304814, Lufotrelvir)
Catalog No. : PC-72751Not For Human Use, Lab Use Only.
PF-07304814 (PF 07304814, Lufotrelvir) is a phosphate prodrug of PF-00835231, which is a potent, selective inhibitor of pan-coronavirus family 3CL pro.
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-7275101
Biological Activity
PF-07304814 (PF 07304814, Lufotrelvir) is a phosphate prodrug of PF-00835231, which is a potent, selective inhibitor of pan-coronavirus family 3CL pro .
Physicochemical Properties
M.Wt
552.521
Formula
C24H33N4O9P
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
(S)-3-((S)-2-(4-Methoxy-1H-indole-2-carboxamido)-4-methylpentanamido)-2-oxo-4-((S)-2-oxopyrrolidin-3-yl)butyl dihydrogen phosphate
References
1. de Vries M, et al. J Virol. 2021 Feb 23;95(10):e01819-20.
2. Liu C, et al. Antiviral Res. 2021 Mar;187:105020.
3. Hoffman RL, et al. J Med Chem. 2020 Nov 12;63(21):12725-12747.
4. Robert L Hoffman, et al. J Med Chem. 2020 Nov 12;63(21):12725-12747.
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