Chemical Structure : PF-07957472
CAS No.:
3041047-51-9
PF-07957472
(PF 07957472)
Catalog No.: PC-22984Not For Human Use, Lab Use Only.
PF-07957472 is a potent, selective, and orally available SARS-CoV-2 papain-like protease (PLpro) inhibitor with Ki of 2 nM, exhibits cell antiviral potency in Vero E6 cells with EC50 of 147 nM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
PF-07957472 is a potent, selective, and orally available SARS-CoV-2 papain-like protease (PLpro) inhibitor with Ki of 2 nM, exhibits cell antiviral potency in Vero E6 cells with EC50 of 147 nM.
PF-07957472 displays no activity against a panel of >100 proteases.
PF-07957472 demonstratespotent viral CPE in dNHBE cells (EC50 = 13.9 nM).
PF-07957472 (20, 50, and 150 mg/kg) is efficacious in a murine SARS-CoV-2 infection model.
PF-07957472 is equally potent on SARS-CoV but nearly inactive on other viruses like MERS, 229E, and OC43.
Physicochemical Properties
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M.Wt
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480.62
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Formula
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C29H32N6O
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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2-methyl-N-(1-(2-(1-methyl-1H-pyrazol-4-yl)quinolin-4-yl)cyclopropyl)-5-(4-methylpiperazin-1-yl)benzamide
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References
1. Garnsey MR, et al. Sci Adv. 2024 Aug 30;10(35):eado4288.
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