PF-1355 (PF-06281355) is a potent, selective, orally active Myeloperoxidase (MPO) inhibitor with EC50 of 1.47 uM.
PF-1355 shows high selectivity over the closely related and clinically relevant thyroid peroxidase enzyme.
PF-1355 inhibits MPO activity in LPS-treated human blood with EC50 of 2.03 uM, blocks HOCl formation in biochemical and cellular assays.
PF-1355 completely blocks kidney injury acutely and prevented any progressive diseasw in anti-GBM glomerulonephritis.
