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PF-219061

Chemical Structure : PF-219061

CAS No.: 710654-74-3

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PF-219061 (PF 219061, PF219061)

Catalog No.: PC-70057Not For Human Use, Lab Use Only.

PF-219061 (PF 219061, PF219061) is a potent, selective agonist of dopamine D3 receptor with EC50 of 8 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    PF-219061 (PF 219061, PF219061) is a potent, selective agonist of dopamine D3 receptor with EC50 of 8 nM.
    PF-219061 has >1000-fold functional selectivity over D2, displays minimal binding activity (IC50>10 uM) against a wide panel of targets including dopamine D1 and D5 receptors.
    PF-219061 demonstrates activity in animal models of male erectile dysfunction.

    Physicochemical Properties

    M.Wt 235.327
    Formula C14H21NO2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3-((2R,5S)-5-methyl-4-propylmorpholin-2-yl)phenol

    References

    1. Blagg J, et al. Bioorg Med Chem Lett. 2007 Dec 15;17(24):6691-6.

    2. Attkins NJ, et al. Xenobiotica. 2009 Jul;39(7):523-33.

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