Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : PF-2771
CAS No.: 2070009-55-9
Catalog No.: PC-45640Not For Human Use, Lab Use Only.
PF-2771 is a potent, selective centromere protein E (CENP-E) inhibitor with IC50 of 16.1 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $198 | In stock | |
| 10 mg | $298 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
PF-2771 is a potent, selective centromere protein E (CENP-E) inhibitor with IC50 of 16.1 nM.
PF-2771 does not inhibit the ATPase activities of highly related kinesins (Eg5/KSP, chromokinesin and MCAK, IC50> 1 uM).
PF-2771 selectively inhibits proliferation of basal breast cancer cell lines.
PF-2771 regresses tumor growth correlated with increased phospho-HH3-Ser10 levels in a breast cancer xenograft tumor model.
| M.Wt | 554.0803 | |
| Formula | C29H36ClN5O4 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
DMSO: ≥ 32 mg/mL |
|
| Chemical Name/SMILES |
(S)-N-(1-(4-(2-acetyl-1-methyl-1H-imidazol-4-yl)phenyl)-3-(2-(dimethylamino)acetamido)propan-2-yl)-3-chloro-4-isopropoxybenzamide |
|
1. Kung PP, et al. Mol Cancer Ther. 2014 Aug;13(8):2104-15.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
