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Chemical Structure : PF-3845
CAS No.: 1196109-52-0
Catalog No.: PC-49009Not For Human Use, Lab Use Only.
PF-3845 is a potent, highly selective, covalent FAAH inhibitor with Ki of 0.23 uM, highly selective for FAAH in the brain.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $178 | In stock | |
| 100 mg | $298 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote | ||
| 5 g | Get quote |
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PF-3845 is a potent, highly selective, covalent FAAH inhibitor with Ki of 0.23 uM, highly selective for FAAH in the brain.
PF-3845 is a covalent inhibitor that carbamylates FAAH's serine nucleophile.
PF-3845 displays an unprecedented combination of in vivo activity and selectivity.
PF-3845 selectively inhibits FAAH in vivo as determined by activity-based protein profiling and raises brain anandamide levels for up to 24 hrs, resulting in profound cannabinoid receptor-dependent reductions in inflammatory pain.
PF-3845 is a valuable pharmacological tool for studying FAAH-regulated endocannabinoid pathways.
| M.Wt | 456.46 | |
| Formula | C24H23F3N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-3-Pyridinyl-4-[[3-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]methyl]-1-piperidinecarboxamide |
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1. Ahn K, et al. Chem Biol. 2009 Apr 24;16(4):411-20.
2. Kinsey SG, et al. J Pain. 2010 Dec;11(12):1420-8.
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