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PF-592379

Chemical Structure : PF-592379

CAS No.: 710655-15-5

PF-592379 (PF592379, PF 592379)

Catalog No.: PC-60216Not For Human Use, Lab Use Only.

PF-592379 is a potent, selective, orally active agonist of dopamine D3 receptor with EC50 of 21 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    PF-592379 is a potent, selective, orally active agonist of dopamine D3 receptor with EC50 of 21 nM.
    PF-592379 displays >470 and 180-fold functional selectivity over D2 and D4 dopamine receptors, respectively.
    PF-592379 demonstrates activity in animal models of male erectile dysfunction.

    Physicochemical Properties

    M.Wt 235.331
    Formula C13H21N3O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    5-[(2R,5S)-5-methyl-4-propylmorpholin-2-yl]pyridin-2-amine

    References

    1. Attkins N, et al. Xenobiotica. 2010 Nov;40(11):730-42.

    2. Collins GT, et al. Behav Pharmacol. 2012 Jun;23(3):280-91.

    3. Thomsen M, et al. J Pharmacol Exp Ther. 2017 Jul;362(1):161-176.

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