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Chemical Structure : PF-739
Catalog No.: PC-60138Not For Human Use, Lab Use Only.
PF-739 (PF739) is a potent, pan-AMPK activator with similar potency for all AMPK heterotrimers, increases the phosphorylation of the AMPK substrate ACC at S79 with EC50 of 121 nM.
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PF-739 (PF739) is a potent, pan-AMPK activator with similar potency for all AMPK heterotrimers, increases the phosphorylation of the AMPK substrate ACC at S79 with EC50 of 121 nM.
PF-739 potently inhibits de novo lipogenesis (IC50=25 nM) in primary rat hepatocytes.
PF-739 increases PGC1a transcription and mitochondrial content, effectively activats AMPK in hepatocytes and in skeletal muscle.
PF-739 treatment caused a rapid lowering of plasma glucose levels with no impact on hepatic glucose production in diabetic mice.
| M.Wt | 442.896 | |
| Formula | C23H23ClN2O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Cokorinos EC, et al. Cell Metab. 2017 May 2;25(5):1147-1159.
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