Catalog No.: PC-60138Not For Human Use, Lab Use Only.
PF-739 (PF739) is a potent, pan-AMPK activator with similar potency for all AMPK heterotrimers, increases the phosphorylation of the AMPK substrate ACC at S79 with EC50 of 121 nM.
PF-739 (PF739) is a potent, pan-AMPK activator with similar potency for all AMPK heterotrimers, increases the phosphorylation of the AMPK substrate ACC at S79 with EC50 of 121 nM.
PF-739 potently inhibits de novo lipogenesis (IC50=25 nM) in primary rat hepatocytes.
PF-739 increases PGC1a transcription and mitochondrial content, effectively activats AMPK in hepatocytes and in skeletal muscle.
PF-739 treatment caused a rapid lowering of plasma glucose levels with no impact on hepatic glucose production in diabetic mice.
