PF-956980 |Cas:1262832-74-5 Buy PF-956980 from ProbeChem, Global Biochemicals Supplier

Chemical Structure : PF-956980

PF-956980 (PF 956980;PF956980)

Catalog No.: PC-60314Not For Human Use, Lab Use Only.

PF-956980 is a potent, highly specific JAK3 inhibitor with IC50 of 4 nM.

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Biological Activity

PF-956980 is a potent, highly specific JAK3 inhibitor with IC50 of 4 nM.
PF-956980 shows only modest inhibition of PKA (6.7 uM) and LCK (10.9 uM) in vitro.
PF-956980 selectively downregulates JAK2 and JAK3 mRNA, corresponding to changes observed at the protein level.
PF-956980 shows in vivo activity consistent with in vitro enzyme and whole blood assays (39 ng/ml).
PF-956980 dose-dependently inhibits the DTH response in mice with EC50 of 5 mg/kg.

Physicochemical Properties

M.Wt	342.44
Formula	C18H26N6O
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	{(3R,4R)-4-Methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-piperidin-1-yl}-pyrrolidin-1-yl-methanone

References

1. Changelian PS, et al. Blood. 2008 Feb 15;111(4):2155-7.

2. Steele AJ, et al. Blood. 2010 Nov 25;116(22):4569-77.

3. Field SD, et al. ACS Chem Biol. 2017 May 19;12(5):1183-1187.

PF-956980 (PF 956980;PF956980)

Biological Activity

Physicochemical Properties

References

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