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Chemical Structure : PF-956980
Catalog No.: PC-60314Not For Human Use, Lab Use Only.
PF-956980 is a potent, highly specific JAK3 inhibitor with IC50 of 4 nM.
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PF-956980 is a potent, highly specific JAK3 inhibitor with IC50 of 4 nM.
PF-956980 shows only modest inhibition of PKA (6.7 uM) and LCK (10.9 uM) in vitro.
PF-956980 selectively downregulates JAK2 and JAK3 mRNA, corresponding to changes observed at the protein level.
PF-956980 shows in vivo activity consistent with in vitro enzyme and whole blood assays (39 ng/ml).
PF-956980 dose-dependently inhibits the DTH response in mice with EC50 of 5 mg/kg.
| M.Wt | 342.44 | |
| Formula | C18H26N6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Changelian PS, et al. Blood. 2008 Feb 15;111(4):2155-7.
2. Steele AJ, et al. Blood. 2010 Nov 25;116(22):4569-77.
3. Field SD, et al. ACS Chem Biol. 2017 May 19;12(5):1183-1187.
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