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PF-AKT400

Chemical Structure : PF-AKT400

CAS No.: 1004990-28-6

PF-AKT400 (AKT protein kinase inhibitor)

Catalog No.: PC-42697Not For Human Use, Lab Use Only.

PF-AKT400 is a broadly selective, potent, ATP-competitive Akt kinase inhibitor with IC50 of 0.5 nM (biochemical assay), and 0.31 nM (cell function assay).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

PF-AKT400 is a broadly selective, potent, ATP-competitive Akt kinase inhibitor with IC50 of 0.5 nM (biochemical assay), and 0.31 nM (cell function assay).
PF-AKT400 shows >900-fold selectivity over PKA.
PF-AKT400 shows excellent PK profiles and effective in in vivo models of xenograft tumor.

Physicochemical Properties

M.Wt 400.4251
Formula C20H22F2N6O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Benzamide, N-[[(3S)-3-amino-1-(5-ethyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-3-pyrrolidinyl]methyl]-2,4-difluoro-

References

1. Freeman-Cook KD, et al. J Med Chem. 2010 Jun 24;53(12):4615-22.

2. Chen SF, et al. J Mol Model. 2013 Nov;19(11):5097-112.

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