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PF-CBP1

Chemical Structure : PF-CBP1

CAS No.: 1962928-21-7

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PF-CBP1 (PF CBP1)

Catalog No.: PC-70031Not For Human Use, Lab Use Only.

PF-CBP1 is a potent, highly selective CBP/p300 bromodomains inhibitor with IC50 of 125 nM and 363 nM, respectively.

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25 mg $138 In stock
50 mg $218 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

PF-CBP1 is a potent, highly selective CBP/p300 bromodomains inhibitor with IC50 of 125 nM and 363 nM, respectively.
PF-CBP1 displays >100-fold selectivity for the bromodomain of CBP over those of BRD4 and a panel of other proteins.
PF-CBP1 reduces the expression of inflammatory cytokines by LPS-stimulated primary macrophages, also suppresses the expression of RGS4 in primary cortical neurons.

Physicochemical Properties

M.Wt 488.6
Formula C29H36N4O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-(2-(5-(3,5-dimethylisoxazol-4-yl)-2-(4-propoxyphenethyl)-1H-benzo[d]imidazol-1-yl)ethyl)morpholine

References

1. Chekler EL, et al. Chem Biol. 2015 Dec 17;22(12):1588-96.

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