PF-DcpSi | DcpS inhibitor | Probechem Biochemicals

Chemical Structure : PF-DcpSi

PF-DcpSi (DcpS inhibitor)

Catalog No.: PC-60223Not For Human Use, Lab Use Only.

PF-DcpSi is a potent inhibitor of the mRNA decapping scavenger enzyme (DcpS) with IC50 of 0.11 nM.

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Biological Activity

PF-DcpSi is a potent inhibitor of the mRNA decapping scavenger enzyme (DcpS) with IC50 of 0.11 nM.
PF-DcpSi shows no significant activity for DHFR (IC50>30 uM).
PF-DcpSi has in vivo mouse CNS PK profile, shows activity in SMA mouse model by prolonging survival and improving function thereby ruling out lysosomotropism.

Physicochemical Properties

M.Wt	309.304
Formula	C16H12FN5O
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-((2,4-diaminoquinazolin-5-yl)methoxy)-5-fluorobenzonitrile

References

1. Gopalsamy A, et al. J Med Chem. 2017 Apr 13;60(7):3094-3108.

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