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Chemical Structure : PF 04942847
Catalog No.: PC-60670Not For Human Use, Lab Use Only.
An orally available, ATP-competitive, small-molecule inhibitor of HSP90 with Ki of 6 nM.
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An orally available, ATP-competitive, small-molecule inhibitor of HSP90 with Ki of 6 nM; maintains potency toward HSP90 client protein degradation in various cellular assay with AKT IC50 of 20-100 nM, demonstrates tumor growth inhibition in the MDA-MB-231 xenograft model.
| M.Wt | 509.918 | |
| Formula | C22H23ClF3N7O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Yamazaki S, et al. J Pharmacol Exp Ther. 2011 Sep;338(3):964-73.
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