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PF04942847

Chemical Structure : PF04942847

CAS No.: 1207961-33-8

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PF04942847 (PF-04942847, PF-4942847)

Catalog No.: PC-60670Not For Human Use, Lab Use Only.

PF04942847 is an orally available, ATP-competitive, small-molecule inhibitor of HSP90 with Ki of 6 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    PF04942847 (PF-04942847, PF-4942847) is an orally available, ATP-competitive, small-molecule inhibitor of HSP90 with Ki of 6 nM.
    PF04942847 maintains potency toward HSP90 client protein degradation in various cellular assay with AKT IC50 of 20-100 nM.
    PF04942847 demonstrates tumor growth inhibition in the MDA-MB-231 xenograft model.

    Physicochemical Properties

    M.Wt 509.918
    Formula C22H23ClF3N7O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-amino-4-{4-chloro-2-[2-(4-fluoro-1H-pyrazol-1-yl)ethoxy]-6-methylphenyl}-N-(2,2-difluoropropyl)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-6-carboxamide

    References

    1. Yamazaki S, et al. J Pharmacol Exp Ther. 2011 Sep;338(3):964-73.

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