PF470 | mGluR5 NAM | Probechem Biochemicals

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Chemical Structure : PF470

PF470 (PF-470)

Catalog No.: PC-61059Not For Human Use, Lab Use Only.

PF470 is a highly potent, selective, and efficacious metabotropic glutamate receptor 5 (mGluR5) negative allosteric modulator with Ki of 0.9 nM, IC50 of 2.5 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

PF470 is a highly potent, selective, and efficacious metabotropic glutamate receptor 5 (mGluR5) negative allosteric modulator with Ki of 0.9 nM, IC50 of 2.5 nM.
PF470 demonstrates robust efficacy in MPTP-rendered Parkinsonian nonhuman primate model of l-DOPA-induced dyskinesia (PD-LID), but with delayed-type immune-mediated type IV hypersensitivity.

Physicochemical Properties

M.Wt	332.367
Formula	C18H16N6O
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1-methyl-3-(4-methylpyridin-3-yl)-6-(pyridin-2-ylmethoxy)-1H-pyrazolo[3,4-b]pyrazine

References

1. Zhang L, et al. J Med Chem. 2014 Feb 13;57(3):861-77.

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PF470 (PF-470)

Biological Activity

Physicochemical Properties

References

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