Catalog No.: PC-38442Not For Human Use, Lab Use Only.
PF9601N (FA-73) is a potent and selective, non-amphetamine type monoamine oxidase B (MAO-B) inhibitor with Ki of 0.75 and 800 nM for MAO-B and MAO-A, respectively.
PF9601N (FA-73) is a potent and selective, non-amphetamine type monoamine oxidase B (MAO-B) inhibitor with Ki of 0.75 and 800 nM for MAO-B and MAO-A, respectively.
PF9601N (FA-73) displays 1066 fold selectivity over MAO-A, and 48 times more selective than L-deprenyl.
PF9601N (FA-73) potently inhibits dopamine uptake in human caudate tissue with IC50 of 0.36 uM.
PF9601N (FA-73) inhibits mouse brain MAO-B activity about 90% ex vivo inhibited by after 4 mg kg(-1) administration, with no effect on MAO-A.
PF9601N (FA-73) significantly reduced MPP(+)-induced caspase-2 activity and PUMA-alpha levels in SH-SY5Y human dopaminergic cells.
PF9601N (FA-73) has shown neuroprotective properties in vivo using different experimental models of Parkinson's disease.
