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Chemical Structure : PF9601N
CAS No.: 133845-63-3
Catalog No.: PC-38442Not For Human Use, Lab Use Only.
PF9601N (FA-73) is a potent and selective, non-amphetamine type monoamine oxidase B (MAO-B) inhibitor with Ki of 0.75 and 800 nM for MAO-B and MAO-A, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $218 | In stock | |
| 50 mg | $388 | In stock | |
| 100 mg | $658 | In stock | |
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PF9601N (FA-73) is a potent and selective, non-amphetamine type monoamine oxidase B (MAO-B) inhibitor with Ki of 0.75 and 800 nM for MAO-B and MAO-A, respectively.
PF9601N (FA-73) displays 1066 fold selectivity over MAO-A, and 48 times more selective than L-deprenyl.
PF9601N (FA-73) potently inhibits dopamine uptake in human caudate tissue with IC50 of 0.36 uM.
PF9601N (FA-73) inhibits mouse brain MAO-B activity about 90% ex vivo inhibited by after 4 mg kg(-1) administration, with no effect on MAO-A.
PF9601N (FA-73) significantly reduced MPP(+)-induced caspase-2 activity and PUMA-alpha levels in SH-SY5Y human dopaminergic cells.
PF9601N (FA-73) has shown neuroprotective properties in vivo using different experimental models of Parkinson's disease.
| M.Wt | 290.366 | |
| Formula | C19H18N2O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
5-(phenylmethoxy)-N-2-propyn-1-yl-1H-indole-2-methanamine |
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1. Sanz E, et al. J Neurochem. 2008 Jun 1;105(6):2404-17.
2. Sanz E, et al. Mol Cell Neurosci. 2009 May;41(1):19-31.
3. Bolea I, et al. CNS Neurosci Ther. 2014 Jul;20(7):641-50.
4. V Pérez, et al. Br J Pharmacol. 1999 Jun;127(4):869-76.
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